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Population pharmacokinetic modeling of piperacillin in critically ill adult patients: consideration of sex-based differences during model development.

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Title: Population pharmacokinetic modeling of piperacillin in critically ill adult patients: consideration of sex-based differences during model development.
Authors: El-Haffaf I; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada., Williamson D; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada., Nguyen VD; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada., Duong A; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada., Williams V; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada., Smith MA; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Albert M; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Blain H; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Goettel N; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Beloin-Jubinville B; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Lamontagne F; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Marsot A; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Centre de Recherche, CHU Sainte-Justine, Montréal, QC, Canada.
Source: Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2026 Jan; Vol. 19 (1), pp. 69-83. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278296 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-2441 (Electronic) Linking ISSN: 17512433 NLM ISO Abbreviation: Expert Rev Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Population pharmacokinetic modeling of piperacillin in critically ill adult patients: consideration of sex-based differences during model development.
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  Data: <searchLink fieldCode="AU" term="%22El-Haffaf+I%22">El-Haffaf I</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Williamson+D%22">Williamson D</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Nguyen+VD%22">Nguyen VD</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Duong+A%22">Duong A</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Williams+V%22">Williams V</searchLink>; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Smith+MA%22">Smith MA</searchLink>; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Albert+M%22">Albert M</searchLink>; CIUSSS-NIM-Hôpital du Sacré-Cœur de Montréal and CIUSSS-NIM Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Blain+H%22">Blain H</searchLink>; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Goettel+N%22">Goettel N</searchLink>; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Beloin-Jubinville+B%22">Beloin-Jubinville B</searchLink>; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Lamontagne+F%22">Lamontagne F</searchLink>; Department of Pharmacy, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Marsot+A%22">Marsot A</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Laboratoire de Suivi Thérapeutique Pharmacologique et Pharmacocinétique, Faculty of Pharmacy, Université de Montréal, Montréal, QC, Canada.; Centre de Recherche, CHU Sainte-Justine, Montréal, QC, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101278296%22">Expert review of clinical pharmacology</searchLink> [Expert Rev Clin Pharmacol] 2026 Jan; Vol. 19 (1), pp. 69-83. <i>Date of Electronic Publication: </i>2026 Jan 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101278296 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1751-2441 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217512433%22">17512433 </searchLink><i>NLM ISO Abbreviation: </i>Expert Rev Clin Pharmacol <i>Subsets: </i>MEDLINE
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