Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.

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Title: Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.
Authors: Elashmony SM; Medical Pharmacology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Alhindi Y; Pharmacology and Toxicology Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Merzeban DH; Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. dhm00@fayoum.edu.eg., Mohammed RA; Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Elsayed AM; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Loqa MG; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mahmoud RH; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Shamardl HA; Medical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Shabana MF; Medical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Source: Journal of molecular histology [J Mol Histol] 2026 Jan 21; Vol. 57 (1), pp. 58. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1567-2387
DOI:10.1007/s10735-025-10668-0