Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.

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Title: Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.
Authors: Elashmony SM; Medical Pharmacology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Alhindi Y; Pharmacology and Toxicology Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Merzeban DH; Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. dhm00@fayoum.edu.eg., Mohammed RA; Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Elsayed AM; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Loqa MG; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mahmoud RH; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Shamardl HA; Medical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Shabana MF; Medical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Source: Journal of molecular histology [J Mol Histol] 2026 Jan 21; Vol. 57 (1), pp. 58. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.
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  Data: <searchLink fieldCode="AU" term="%22Elashmony+SM%22">Elashmony SM</searchLink>; Medical Pharmacology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Alhindi+Y%22">Alhindi Y</searchLink>; Pharmacology and Toxicology Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Merzeban+DH%22">Merzeban DH</searchLink>; Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. dhm00@fayoum.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mohammed+RA%22">Mohammed RA</searchLink>; Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22Elsayed+AM%22">Elsayed AM</searchLink>; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22Loqa+MG%22">Loqa MG</searchLink>; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22Mahmoud+RH%22">Mahmoud RH</searchLink>; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22Shamardl+HA%22">Shamardl HA</searchLink>; Medical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22Shabana+MF%22">Shabana MF</searchLink>; Medical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101193653%22">Journal of molecular histology</searchLink> [J Mol Histol] 2026 Jan 21; Vol. 57 (1), pp. 58. <i>Date of Electronic Publication: </i>2026 Jan 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Netherlands%22">Springer Netherlands </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101193653 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1567-2387 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215672379%22">15672379 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Histol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10735-025-10668-0
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        Text: English
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        StartPage: 58
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      – TitleFull: Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.
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              Text: 2026 Jan 21
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