Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial.
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| Title: | Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial. |
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| Authors: | Salminen P; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Surgery, University of Turku, Turku, Finland., Salminen R; Department of Surgery, University of Turku, Turku, Finland.; Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland., Kallio J; Department of Radiology, Turku University Hospital, Turku, Finland., Hurme S; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland., Nordström P; Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland., Rantanen T; Department of Surgery, Kuopio University Hospital, Kuopio, Finland.; Department of Surgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Paajanen H; Department of Surgery, Mikkeli Central Hospital, Mikkeli, Finland., Aarnio M; Department of Education and Research, Wellbeing Services County of Central Finland, Jyväskylä, Finland., Mecklin JP; Department of Education and Research, Wellbeing Services County of Central Finland, Jyväskylä, Finland., Sand J; Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland., Grönroos JM; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Surgery, University of Turku, Turku, Finland., Rautio T; Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland. |
| Source: | JAMA [JAMA] 2026 Mar 24; Vol. 335 (12), pp. 1041-1049. |
| Publication Type: | Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2025.25921 |
