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Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial.

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Title: Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial.
Authors: Salminen P; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Surgery, University of Turku, Turku, Finland., Salminen R; Department of Surgery, University of Turku, Turku, Finland.; Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland., Kallio J; Department of Radiology, Turku University Hospital, Turku, Finland., Hurme S; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland., Nordström P; Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland., Rantanen T; Department of Surgery, Kuopio University Hospital, Kuopio, Finland.; Department of Surgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Paajanen H; Department of Surgery, Mikkeli Central Hospital, Mikkeli, Finland., Aarnio M; Department of Education and Research, Wellbeing Services County of Central Finland, Jyväskylä, Finland., Mecklin JP; Department of Education and Research, Wellbeing Services County of Central Finland, Jyväskylä, Finland., Sand J; Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland., Grönroos JM; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Surgery, University of Turku, Turku, Finland., Rautio T; Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Source: JAMA [JAMA] 2026 Mar 24; Vol. 335 (12), pp. 1041-1049.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Salminen+P%22">Salminen P</searchLink>; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Surgery, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Salminen+R%22">Salminen R</searchLink>; Department of Surgery, University of Turku, Turku, Finland.; Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Kallio+J%22">Kallio J</searchLink>; Department of Radiology, Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Hurme+S%22">Hurme S</searchLink>; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Nordström+P%22">Nordström P</searchLink>; Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Rantanen+T%22">Rantanen T</searchLink>; Department of Surgery, Kuopio University Hospital, Kuopio, Finland.; Department of Surgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Paajanen+H%22">Paajanen H</searchLink>; Department of Surgery, Mikkeli Central Hospital, Mikkeli, Finland.<br /><searchLink fieldCode="AU" term="%22Aarnio+M%22">Aarnio M</searchLink>; Department of Education and Research, Wellbeing Services County of Central Finland, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Mecklin+JP%22">Mecklin JP</searchLink>; Department of Education and Research, Wellbeing Services County of Central Finland, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Sand+J%22">Sand J</searchLink>; Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Grönroos+JM%22">Grönroos JM</searchLink>; Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.; Department of Surgery, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Rautio+T%22">Rautio T</searchLink>; Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
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  Data: <searchLink fieldCode="JN" term="%227501160%22">JAMA</searchLink> [JAMA] 2026 Mar 24; Vol. 335 (12), pp. 1041-1049.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7501160 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-3598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200987484%22">00987484 </searchLink><i>NLM ISO Abbreviation: </i>JAMA <i>Subsets: </i>MEDLINE
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