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In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.

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Title: In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.
Authors: Gacem N; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Bezukladova S; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Windener F; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Karam T; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Ottoboni L; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Brambilla E; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Ruffini F; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Soman K; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA., Garcia-Diaz B; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Levy MJF; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Cui QL; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Formato A; Department of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy., Deboux C; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Chazot J; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Panic R; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Albrecht S; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Yilmaz EN; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., González RG; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Eberini I; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy., Olla S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042 Monserrato, Italy., Bresciani A; IRBM S.p.A., Pomezia, Rome 00071, Italy., Goebels N; Department of Neurology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany., Zipp F; Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine-Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Agresti C; Department of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy., Antel J; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Evercooren AB; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Kuhlmann T; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Baranzini SE; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA., Panina-Bordignon P; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Nait-Oumesmar B; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Martino G; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.
Source: Science translational medicine [Sci Transl Med] 2026 Jan 21; Vol. 18 (833), pp. eads0633. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Gacem+N%22">Gacem N</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Bezukladova+S%22">Bezukladova S</searchLink>; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Windener+F%22">Windener F</searchLink>; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Karam+T%22">Karam T</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Ottoboni+L%22">Ottoboni L</searchLink>; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brambilla+E%22">Brambilla E</searchLink>; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ruffini+F%22">Ruffini F</searchLink>; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Soman+K%22">Soman K</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Diaz+B%22">Garcia-Diaz B</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Levy+MJF%22">Levy MJF</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Cui+QL%22">Cui QL</searchLink>; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Formato+A%22">Formato A</searchLink>; Department of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Deboux+C%22">Deboux C</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Chazot+J%22">Chazot J</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Panic+R%22">Panic R</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Albrecht+S%22">Albrecht S</searchLink>; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Yilmaz+EN%22">Yilmaz EN</searchLink>; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22González+RG%22">González RG</searchLink>; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Eberini+I%22">Eberini I</searchLink>; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Olla+S%22">Olla S</searchLink>; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042 Monserrato, Italy.<br /><searchLink fieldCode="AU" term="%22Bresciani+A%22">Bresciani A</searchLink>; IRBM S.p.A., Pomezia, Rome 00071, Italy.<br /><searchLink fieldCode="AU" term="%22Goebels+N%22">Goebels N</searchLink>; Department of Neurology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Zipp+F%22">Zipp F</searchLink>; Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine-Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Agresti+C%22">Agresti C</searchLink>; Department of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antel+J%22">Antel J</searchLink>; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Evercooren+AB%22">Evercooren AB</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Kuhlmann+T%22">Kuhlmann T</searchLink>; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Baranzini+SE%22">Baranzini SE</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Panina-Bordignon+P%22">Panina-Bordignon P</searchLink>; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Nait-Oumesmar+B%22">Nait-Oumesmar B</searchLink>; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Martino+G%22">Martino G</searchLink>; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy.
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