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Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.

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Title: Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.
Authors: Pimenta EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Garza AE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Camp SY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Hoffman SE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Division of Medical Sciences PhD Program in Biological and Biomedical Sciences, Boston, MA 02115, USA.; Harvard-MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA., Valderrábano L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Fu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA 02115, USA., Bi K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Carson MT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Karam J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Titchen BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Division of Medical Sciences PhD Program in Biological and Biomedical Sciences, Boston, MA 02115, USA., Medjahed S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Khandekar MJ; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA., Shannon E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Kang YJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA., Coy S; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Ludwig Center at Harvard, Boston, MA 02115, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Lin JR; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Nag A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Thorner AR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Gibson WJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Santagata S; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Raut CP; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA., Hornick JL; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA., Merriam P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Solimini NL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Ludwig Center at Harvard, Boston, MA 02115, USA., George S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Demetri GD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Ludwig Center at Harvard, Boston, MA 02115, USA., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jan 21; Vol. 18 (833), pp. eadw4689. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.
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  Data: <searchLink fieldCode="AU" term="%22Pimenta+EM%22">Pimenta EM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Garza+AE%22">Garza AE</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Camp+SY%22">Camp SY</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+SE%22">Hoffman SE</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Division of Medical Sciences PhD Program in Biological and Biomedical Sciences, Boston, MA 02115, USA.; Harvard-MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Valderrábano+L%22">Valderrábano L</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bi+K%22">Bi K</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Carson+MT%22">Carson MT</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Karam+J%22">Karam J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Titchen+BM%22">Titchen BM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Division of Medical Sciences PhD Program in Biological and Biomedical Sciences, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Medjahed+S%22">Medjahed S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Khandekar+MJ%22">Khandekar MJ</searchLink>; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Shannon+E%22">Shannon E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Kang+YJ%22">Kang YJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Coy+S%22">Coy S</searchLink>; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Ludwig Center at Harvard, Boston, MA 02115, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lin+JR%22">Lin JR</searchLink>; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Nag+A%22">Nag A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Thorner+AR%22">Thorner AR</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+WJ%22">Gibson WJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Santagata+S%22">Santagata S</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Raut+CP%22">Raut CP</searchLink>; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hornick+JL%22">Hornick JL</searchLink>; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Merriam+P%22">Merriam P</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Solimini+NL%22">Solimini NL</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Ludwig Center at Harvard, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22George+S%22">George S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Demetri+GD%22">Demetri GD</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Ludwig Center at Harvard, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Van+Allen+EM%22">Van Allen EM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; David Liposarcoma Research Initiative, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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