Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.

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Title: Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.
Authors: Viswanathan G; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Hughes EJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University School of Medicine, Durham, NC 27710, USA., Gan M; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Xet-Mull AM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Lowy JP; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University School of Medicine, Durham, NC 27710, USA., Pyle CJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Alexander G; Sequencing and Genomics Technologies Core Facility, Duke University School of Medicine, Durham, NC 27710, USA., Swain-Lenz D; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Sequencing and Genomics Technologies Core Facility, Duke University School of Medicine, Durham, NC 27710, USA., Liu Q; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Tobin DM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Source: Science advances [Sci Adv] 2026 Jan 23; Vol. 12 (4), pp. eadw4619. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.adw4619