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Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.

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Title: Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.
Authors: Viswanathan G; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Hughes EJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University School of Medicine, Durham, NC 27710, USA., Gan M; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Xet-Mull AM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Lowy JP; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University School of Medicine, Durham, NC 27710, USA., Pyle CJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Alexander G; Sequencing and Genomics Technologies Core Facility, Duke University School of Medicine, Durham, NC 27710, USA., Swain-Lenz D; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Sequencing and Genomics Technologies Core Facility, Duke University School of Medicine, Durham, NC 27710, USA., Liu Q; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Tobin DM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Source: Science advances [Sci Adv] 2026 Jan 23; Vol. 12 (4), pp. eadw4619. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.
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  Data: <searchLink fieldCode="AU" term="%22Viswanathan+G%22">Viswanathan G</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+EJ%22">Hughes EJ</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Gan+M%22">Gan M</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Xet-Mull+AM%22">Xet-Mull AM</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Lowy+JP%22">Lowy JP</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Pyle+CJ%22">Pyle CJ</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+G%22">Alexander G</searchLink>; Sequencing and Genomics Technologies Core Facility, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Swain-Lenz+D%22">Swain-Lenz D</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Sequencing and Genomics Technologies Core Facility, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Tobin+DM%22">Tobin DM</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Jan 23; Vol. 12 (4), pp. eadw4619. <i>Date of Electronic Publication: </i>2026 Jan 21.
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              Text: 2026 Jan 23
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