CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

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Title: CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.
Authors: Watterson A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Picco G; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Veninga V; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands., Samarakoon Y; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK., Cattaneo CM; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands., Vieira SF; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Karakoc E; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Bhosle S; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK., Battaglia TW; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Consonni S; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Halim TYF; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK., Voest EE; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands., Garnett MJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Coelho MA; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK. Electronic address: matthew.coelho@sanger.ac.uk.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jan 20; Vol. 7 (1), pp. 102565.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2666-3791
DOI:10.1016/j.xcrm.2025.102565