Updated recommendations for the design of therapeutic trials for neonatal seizures.

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Title: Updated recommendations for the design of therapeutic trials for neonatal seizures.
Authors: Soul JS; Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Janet.Soul@childrens.harvard.edu., Wang S; Department of Neurology and Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA., Sharpe C; Department of Paediatric Neurology, Starship Children's Hospital, Auckland, New Zealand.; Department of Neurosciences, University of California, San Diego, CA, USA., Pilon B; Hope for HIE, MI, West Bloomfield, USA., Pressler RM; Clinical Neuroscience, UCL GOS Institute of Child Health and Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Allen MC; Department of Pediatrics, Johns Hopkins School of Medicine, Infant Neurodevelopmental Center, Kennedy Krieger Institute, Baltimore, MD, USA., Ali F; Paediatric Unit, Innovative Medicines, Healthcare Quality & Access, MHRA, London, UK., Auvin S; Pediatric Neurology Department, Reference Center for Rare Epilepsies, Member of ERN Epicare, Hôpital Universitaire Robert Debré, Paris, France.; Institut Hospitalo-Universitaire Robert-Debré du Cerveau de l'Enfant, Paris, France.; Université Paris-Cité, INSERM NeuroDiderot, Paris, France.; Institut Universitaire de France (IUF), Paris, France., Barry C; The Critical Path Institute, Tucson, AZ, USA., Denne S; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Glass HC; Department of Neurology and Weill Institute for Neurosciences, Department of Pediatrics, and Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA., Klein AV; Health Canada, Toronto, ON, Canada., Marlow N; UCL EGA Institute for Women's Health, University College London, London, UK., Rabe H; Department of Academic Paediatrics, Brighton and Sussex Medical School, University of Brighton and University of Sussex, Brighton, UK.; Department of Neonatology, University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital, Brighton, UK., Singh K; The Critical Path Institute, Tucson, AZ, USA., Hovinga C; The Critical Path Institute, Tucson, AZ, USA.
Corporate Authors: International Neonatal Consortium
Source: Pediatric research [Pediatr Res] 2026 Jan 21. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1530-0447
DOI:10.1038/s41390-025-04735-1