Increased Plasma Concentrations of 6-oxo-Methylphenidate in CES1 G134E Carriers Following a Single Oral Dose of Methylphenidate.

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Title: Increased Plasma Concentrations of 6-oxo-Methylphenidate in CES1 G134E Carriers Following a Single Oral Dose of Methylphenidate.
Authors: Zhang Q; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA., Melchert PW; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA., Awad A; Department of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA., McCurdy CR; Department of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA., Krone B; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States., Newcorn J; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States., Froehlich TE; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Stein MA; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195, USA., Raeuscher J; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA., Zhu HJ; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, 48109, USA., Markowitz JS; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.; Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, Florida, 32610, USA.
Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2025 Nov; Vol. 34 (11), pp. 2318-2327. Date of Electronic Publication: 2025 Oct 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1054-2523 (Print) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1054-2523
DOI:10.1007/s00044-025-03477-3