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Increased Plasma Concentrations of 6-oxo-Methylphenidate in CES1 G134E Carriers Following a Single Oral Dose of Methylphenidate.

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Title: Increased Plasma Concentrations of 6-oxo-Methylphenidate in CES1 G134E Carriers Following a Single Oral Dose of Methylphenidate.
Authors: Zhang Q; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA., Melchert PW; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA., Awad A; Department of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA., McCurdy CR; Department of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA., Krone B; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States., Newcorn J; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States., Froehlich TE; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Stein MA; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195, USA., Raeuscher J; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA., Zhu HJ; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, 48109, USA., Markowitz JS; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.; Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, Florida, 32610, USA.
Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2025 Nov; Vol. 34 (11), pp. 2318-2327. Date of Electronic Publication: 2025 Oct 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1054-2523 (Print) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Increased Plasma Concentrations of 6-oxo-Methylphenidate in CES1 G134E Carriers Following a Single Oral Dose of Methylphenidate.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Melchert+PW%22">Melchert PW</searchLink>; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Awad+A%22">Awad A</searchLink>; Department of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22McCurdy+CR%22">McCurdy CR</searchLink>; Department of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Krone+B%22">Krone B</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.<br /><searchLink fieldCode="AU" term="%22Newcorn+J%22">Newcorn J</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.<br /><searchLink fieldCode="AU" term="%22Froehlich+TE%22">Froehlich TE</searchLink>; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.<br /><searchLink fieldCode="AU" term="%22Stein+MA%22">Stein MA</searchLink>; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Raeuscher+J%22">Raeuscher J</searchLink>; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+HJ%22">Zhu HJ</searchLink>; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Markowitz+JS%22">Markowitz JS</searchLink>; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.; Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, Florida, 32610, USA.
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  Data: <searchLink fieldCode="JN" term="%229211347%22">Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents</searchLink> [Med Chem Res] 2025 Nov; Vol. 34 (11), pp. 2318-2327. <i>Date of Electronic Publication: </i>2025 Oct 02.
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              Text: 2025 Nov
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