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ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.

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Title: ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.
Authors: Nah GSS; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Chong YK; Department of Research, National Neuroscience Institute, Singapore, Singapore., Sulaimi FN; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Lee KL; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Lim SW; Department of Research, National Neuroscience Institute, Singapore, Singapore., Pang QY; Department of Research, National Neuroscience Institute, Singapore, Singapore., Yu M; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Neo ZW; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Iqbal J; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Nacro K; Experimental Drug Development Centre , A*STAR, Singapore, Singapore., Hill J; Experimental Drug Development Centre , A*STAR, Singapore, Singapore., Matter A; Experimental Drug Development Centre , A*STAR, Singapore, Singapore., Yang H; Cancer Science Institute, National University of Singapore, Singapore, Singapore., Ang BT; Department of Research, National Neuroscience Institute, Singapore, Singapore.; SingHealth Duke-NUS Neuroscience Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore., Tang C; Department of Research, National Neuroscience Institute, Singapore, Singapore., Ong ST; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Hematology, Singapore General Hospital, Singapore, Singapore.; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Source: Cancer research [Cancer Res] 2026 Apr 15; Vol. 86 (8), pp. 2060-2077.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-24-4388