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ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.

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Title: ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.
Authors: Nah GSS; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Chong YK; Department of Research, National Neuroscience Institute, Singapore, Singapore., Sulaimi FN; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Lee KL; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Lim SW; Department of Research, National Neuroscience Institute, Singapore, Singapore., Pang QY; Department of Research, National Neuroscience Institute, Singapore, Singapore., Yu M; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore., Neo ZW; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Iqbal J; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Nacro K; Experimental Drug Development Centre , A*STAR, Singapore, Singapore., Hill J; Experimental Drug Development Centre , A*STAR, Singapore, Singapore., Matter A; Experimental Drug Development Centre , A*STAR, Singapore, Singapore., Yang H; Cancer Science Institute, National University of Singapore, Singapore, Singapore., Ang BT; Department of Research, National Neuroscience Institute, Singapore, Singapore.; SingHealth Duke-NUS Neuroscience Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore., Tang C; Department of Research, National Neuroscience Institute, Singapore, Singapore., Ong ST; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Hematology, Singapore General Hospital, Singapore, Singapore.; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Source: Cancer research [Cancer Res] 2026 Apr 15; Vol. 86 (8), pp. 2060-2077.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Nah+GSS%22">Nah GSS</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+YK%22">Chong YK</searchLink>; Department of Research, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sulaimi+FN%22">Sulaimi FN</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+KL%22">Lee KL</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+SW%22">Lim SW</searchLink>; Department of Research, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pang+QY%22">Pang QY</searchLink>; Department of Research, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+M%22">Yu M</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Neo+ZW%22">Neo ZW</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Iqbal+J%22">Iqbal J</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nacro+K%22">Nacro K</searchLink>; Experimental Drug Development Centre , A*STAR, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hill+J%22">Hill J</searchLink>; Experimental Drug Development Centre , A*STAR, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Matter+A%22">Matter A</searchLink>; Experimental Drug Development Centre , A*STAR, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Cancer Science Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ang+BT%22">Ang BT</searchLink>; Department of Research, National Neuroscience Institute, Singapore, Singapore.; SingHealth Duke-NUS Neuroscience Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tang+C%22">Tang C</searchLink>; Department of Research, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+ST%22">Ong ST</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Hematology, Singapore General Hospital, Singapore, Singapore.; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2026 Apr 15; Vol. 86 (8), pp. 2060-2077.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 15
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