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Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.

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Title: Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.
Authors: Hannan SB; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. saadhannan@fas.harvard.edu.; Department of Molecular and Cellular Biology, Harvard University; 52 Oxford Street Cambridge, Cambridge, MA, USA. saadhannan@fas.harvard.edu., Alić I; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia., Murray A; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kwon J; Department of Life Science, Chung-Ang University; 84 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea., Mortensen M; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Kang HJ; Department of Life Science, Chung-Ang University; 84 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea., Plećaš A; Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia., Goh PA; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., O'Brien NL; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Naud R; Department of Cellular and Molecular Medicine, University of Ottawa; 451 Smyth Rd, Ottawa, ON, Canada., Nižetić D; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. d.nizetic@qmul.ac.uk., Smart TG; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. t.smart@ucl.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jan 22; Vol. 17 (1), pp. 1287. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Hannan+SB%22">Hannan SB</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. saadhannan@fas.harvard.edu.; Department of Molecular and Cellular Biology, Harvard University; 52 Oxford Street Cambridge, Cambridge, MA, USA. saadhannan@fas.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Alić+I%22">Alić I</searchLink>; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Murray+A%22">Murray A</searchLink>; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kwon+J%22">Kwon J</searchLink>; Department of Life Science, Chung-Ang University; 84 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Mortensen+M%22">Mortensen M</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kang+HJ%22">Kang HJ</searchLink>; Department of Life Science, Chung-Ang University; 84 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Plećaš+A%22">Plećaš A</searchLink>; Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Goh+PA%22">Goh PA</searchLink>; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Brien+NL%22">O'Brien NL</searchLink>; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Naud+R%22">Naud R</searchLink>; Department of Cellular and Molecular Medicine, University of Ottawa; 451 Smyth Rd, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Nižetić+D%22">Nižetić D</searchLink>; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. d.nizetic@qmul.ac.uk.<br /><searchLink fieldCode="AU" term="%22Smart+TG%22">Smart TG</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. t.smart@ucl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 22; Vol. 17 (1), pp. 1287. <i>Date of Electronic Publication: </i>2026 Jan 22.
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