The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production.
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| Title: | The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production. |
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| Authors: | Feng Z; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Wang L; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China., Chen S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Cao S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Lei M; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China., Yang X; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Ma K; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510182, China., Yu S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Hu H; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Zheng K; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China., Xu X; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China., Zheng Q; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Wang S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510182, China., Hu W; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 511436, China., Lim CY; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China. lin_junyan@gzlab.ac.cn. |
| Source: | The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (4), pp. 1136-1174. Date of Electronic Publication: 2026 Jan 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00695-2 |
