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The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production.

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Title: The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production.
Authors: Feng Z; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Wang L; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China., Chen S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Cao S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Lei M; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China., Yang X; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Ma K; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510182, China., Yu S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Hu H; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Zheng K; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China., Xu X; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China., Zheng Q; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China., Wang S; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510182, China., Hu W; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 511436, China., Lim CY; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China. lin_junyan@gzlab.ac.cn.
Source: The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (4), pp. 1136-1174. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production.
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  Data: <searchLink fieldCode="AU" term="%22Feng+Z%22">Feng Z</searchLink>; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Lei+M%22">Lei M</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Ma+K%22">Ma K</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510182, China.<br /><searchLink fieldCode="AU" term="%22Yu+S%22">Yu S</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Zheng+K%22">Zheng K</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Q%22">Zheng Q</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510182, China.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China.; GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 511436, China.<br /><searchLink fieldCode="AU" term="%22Lim+CY%22">Lim CY</searchLink>; School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, 510005, China. lin_junyan@gzlab.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Feb; Vol. 45 (4), pp. 1136-1174. <i>Date of Electronic Publication: </i>2026 Jan 22.
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        Value: 10.1038/s44318-026-00695-2
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