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Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.

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Title: Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
Authors: Bräuer S; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Sondermann V; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Schniewind I; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Hähnel T; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Dinter E; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Kleineidam L; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Stark M; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Sodenkamp S; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Spruth E; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Priller J; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Bürger K; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kilimann I; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Teipel S; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Storch A; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, University Medical Centre, Rostock, Germany., Hansen N; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Preis L; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany., Hellmann-Regen J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany., Wagner M; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Bernhardt A; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany., Petzold G; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Vascular Neurology, Centre for Neurology, University Hospital Bonn, Bonn, Germany., Kronmüller M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Gamez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Parkinson's, Sleep and Movement Disorders, Centre for Neurology, University Hospital Bonn, Bonn, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Rostamzadeh A; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Hermann A; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, Translational Neurodegeneration Section 'Albrecht-Kossel,' University Medical Center Rostock, University of Rostock, Rostock, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Falkenburger BH; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jan; Vol. 22 (1), pp. e71167.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1552-5279
DOI:10.1002/alz.71167