View in EDS HTML Full Text PDF Full Text

Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.

Saved in:
Bibliographic Details
Title: Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
Authors: Bräuer S; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Sondermann V; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Schniewind I; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Hähnel T; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Dinter E; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany., Kleineidam L; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Stark M; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Sodenkamp S; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Spruth E; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Priller J; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Bürger K; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kilimann I; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Teipel S; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Storch A; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, University Medical Centre, Rostock, Germany., Hansen N; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Preis L; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany., Hellmann-Regen J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany., Wagner M; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Bernhardt A; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany., Petzold G; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Vascular Neurology, Centre for Neurology, University Hospital Bonn, Bonn, Germany., Kronmüller M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Gamez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Parkinson's, Sleep and Movement Disorders, Centre for Neurology, University Hospital Bonn, Bonn, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Rostamzadeh A; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Hermann A; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, Translational Neurodegeneration Section 'Albrecht-Kossel,' University Medical Center Rostock, University of Rostock, Rostock, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Falkenburger BH; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jan; Vol. 22 (1), pp. e71167.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41572624
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Bräuer+S%22">Bräuer S</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Sondermann+V%22">Sondermann V</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schniewind+I%22">Schniewind I</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Hähnel+T%22">Hähnel T</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Dinter+E%22">Dinter E</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kleineidam+L%22">Kleineidam L</searchLink>; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Stark+M%22">Stark M</searchLink>; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+M%22">Schmid M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Sodenkamp+S%22">Sodenkamp S</searchLink>; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Laske+C%22">Laske C</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Spruth+E%22">Spruth E</searchLink>; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Priller+J%22">Priller J</searchLink>; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Janowitz+D%22">Janowitz D</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bürger+K%22">Bürger K</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kilimann+I%22">Kilimann I</searchLink>; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Teipel+S%22">Teipel S</searchLink>; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Storch+A%22">Storch A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, University Medical Centre, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+N%22">Hansen N</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Glanz+W%22">Glanz W</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Düzel+E%22">Düzel E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Preis+L%22">Preis L</searchLink>; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hellmann-Regen+J%22">Hellmann-Regen J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Bernhardt+A%22">Bernhardt A</searchLink>; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Levin+J%22">Levin J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Petzold+G%22">Petzold G</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Vascular Neurology, Centre for Neurology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kronmüller+M%22">Kronmüller M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Gamez+A%22">Gamez A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Spottke+A%22">Spottke A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic for Parkinson's, Sleep and Movement Disorders, Centre for Neurology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Brosseron+F%22">Brosseron F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Rostamzadeh+A%22">Rostamzadeh A</searchLink>; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Jessen+F%22">Jessen F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+A%22">Hermann A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, Translational Neurodegeneration Section 'Albrecht-Kossel,' University Medical Center Rostock, University of Rostock, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Fliessbach+K%22">Fliessbach K</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenburger+BH%22">Falkenburger BH</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Jan; Vol. 22 (1), pp. e71167.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41572624
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/alz.71167
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e71167
    Titles:
      – TitleFull: Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bräuer S
      – PersonEntity:
          Name:
            NameFull: Sondermann V
      – PersonEntity:
          Name:
            NameFull: Schniewind I
      – PersonEntity:
          Name:
            NameFull: Hähnel T
      – PersonEntity:
          Name:
            NameFull: Dinter E
      – PersonEntity:
          Name:
            NameFull: Kleineidam L
      – PersonEntity:
          Name:
            NameFull: Stark M
      – PersonEntity:
          Name:
            NameFull: Schmid M
      – PersonEntity:
          Name:
            NameFull: Sodenkamp S
      – PersonEntity:
          Name:
            NameFull: Laske C
      – PersonEntity:
          Name:
            NameFull: Spruth E
      – PersonEntity:
          Name:
            NameFull: Priller J
      – PersonEntity:
          Name:
            NameFull: Janowitz D
      – PersonEntity:
          Name:
            NameFull: Bürger K
      – PersonEntity:
          Name:
            NameFull: Kilimann I
      – PersonEntity:
          Name:
            NameFull: Teipel S
      – PersonEntity:
          Name:
            NameFull: Storch A
      – PersonEntity:
          Name:
            NameFull: Hansen N
      – PersonEntity:
          Name:
            NameFull: Wiltfang J
      – PersonEntity:
          Name:
            NameFull: Glanz W
      – PersonEntity:
          Name:
            NameFull: Düzel E
      – PersonEntity:
          Name:
            NameFull: Preis L
      – PersonEntity:
          Name:
            NameFull: Peters O
      – PersonEntity:
          Name:
            NameFull: Hellmann-Regen J
      – PersonEntity:
          Name:
            NameFull: Wagner M
      – PersonEntity:
          Name:
            NameFull: Bernhardt A
      – PersonEntity:
          Name:
            NameFull: Levin J
      – PersonEntity:
          Name:
            NameFull: Petzold G
      – PersonEntity:
          Name:
            NameFull: Kronmüller M
      – PersonEntity:
          Name:
            NameFull: Gamez A
      – PersonEntity:
          Name:
            NameFull: Spottke A
      – PersonEntity:
          Name:
            NameFull: Brosseron F
      – PersonEntity:
          Name:
            NameFull: Rostamzadeh A
      – PersonEntity:
          Name:
            NameFull: Jessen F
      – PersonEntity:
          Name:
            NameFull: Hermann A
      – PersonEntity:
          Name:
            NameFull: Fliessbach K
      – PersonEntity:
          Name:
            NameFull: Schneider A
      – PersonEntity:
          Name:
            NameFull: Falkenburger BH
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: 2026 Jan
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1552-5279
          Numbering:
            – Type: volume
              Value: 22
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Alzheimer's & dementia : the journal of the Alzheimer's Association
              Type: main
ResultId 1