Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants.

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Title: Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants.
Authors: Fraser KB; Biogen Inc, Cambridge, MA, USA., Mirelman A; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Mabrouk OS; Biogen Inc, Cambridge, MA, USA., Omer N; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Concha-Marambio L; Amprion Inc, San Diego, CA, USA., Gurevich T; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Bar-Shira A; Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Gana-Weisz M; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel., Goldstein O; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel., Orr-Urtreger A; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel., Kestenbaum M; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Neurology Department, Meir Medical Center, Kfar Saba, Israel., Cedarbaum JM; Biogen Inc, Cambridge, MA, USA.; Coeruleus Clinical Sciences LLC, Woodbridge, CT, USA., Dam T; Former Biogen employee., Shirvan JC; Former Biogen employee., Giladi N; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Graham D; Biogen Inc, Cambridge, MA, USA., Alcalay RN; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Thaler A; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Source: Journal of Parkinson's disease [J Parkinsons Dis] 2026 Mar; Vol. 16 (2), pp. 205-216. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1877-718X
DOI:10.1177/1877718X251392799