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Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants.

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Title: Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants.
Authors: Fraser KB; Biogen Inc, Cambridge, MA, USA., Mirelman A; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Mabrouk OS; Biogen Inc, Cambridge, MA, USA., Omer N; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Concha-Marambio L; Amprion Inc, San Diego, CA, USA., Gurevich T; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Bar-Shira A; Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Gana-Weisz M; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel., Goldstein O; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel., Orr-Urtreger A; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel., Kestenbaum M; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Neurology Department, Meir Medical Center, Kfar Saba, Israel., Cedarbaum JM; Biogen Inc, Cambridge, MA, USA.; Coeruleus Clinical Sciences LLC, Woodbridge, CT, USA., Dam T; Former Biogen employee., Shirvan JC; Former Biogen employee., Giladi N; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Graham D; Biogen Inc, Cambridge, MA, USA., Alcalay RN; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Thaler A; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Source: Journal of Parkinson's disease [J Parkinsons Dis] 2026 Mar; Vol. 16 (2), pp. 205-216. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants.
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  Data: <searchLink fieldCode="AU" term="%22Fraser+KB%22">Fraser KB</searchLink>; Biogen Inc, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mirelman+A%22">Mirelman A</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Mabrouk+OS%22">Mabrouk OS</searchLink>; Biogen Inc, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Omer+N%22">Omer N</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Concha-Marambio+L%22">Concha-Marambio L</searchLink>; Amprion Inc, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gurevich+T%22">Gurevich T</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Bar-Shira+A%22">Bar-Shira A</searchLink>; Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Gana-Weisz+M%22">Gana-Weisz M</searchLink>; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Goldstein+O%22">Goldstein O</searchLink>; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Orr-Urtreger+A%22">Orr-Urtreger A</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Kestenbaum+M%22">Kestenbaum M</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Neurology Department, Meir Medical Center, Kfar Saba, Israel.<br /><searchLink fieldCode="AU" term="%22Cedarbaum+JM%22">Cedarbaum JM</searchLink>; Biogen Inc, Cambridge, MA, USA.; Coeruleus Clinical Sciences LLC, Woodbridge, CT, USA.<br /><searchLink fieldCode="AU" term="%22Dam+T%22">Dam T</searchLink>; Former Biogen employee.<br /><searchLink fieldCode="AU" term="%22Shirvan+JC%22">Shirvan JC</searchLink>; Former Biogen employee.<br /><searchLink fieldCode="AU" term="%22Giladi+N%22">Giladi N</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Graham+D%22">Graham D</searchLink>; Biogen Inc, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alcalay+RN%22">Alcalay RN</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Thaler+A%22">Thaler A</searchLink>; Gray Faculty of Medical Health and Sciences, Tel Aviv University, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Movement Disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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  Data: <searchLink fieldCode="JN" term="%22101567362%22">Journal of Parkinson's disease</searchLink> [J Parkinsons Dis] 2026 Mar; Vol. 16 (2), pp. 205-216. <i>Date of Electronic Publication: </i>2026 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22IOS+Press%22">IOS Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101567362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1877-718X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218777171%22">18777171 </searchLink><i>NLM ISO Abbreviation: </i>J Parkinsons Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1177/1877718X251392799
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        Text: English
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              Text: 2026 Mar
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