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Discovery and Characterization of Zelnecirnon (RPT193), a Potent and Selective CCR4 Antagonist for Allergic Disorders.

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Title: Discovery and Characterization of Zelnecirnon (RPT193), a Potent and Selective CCR4 Antagonist for Allergic Disorders.
Authors: Zibinsky M; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Bradford D; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Brockstedt DG; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Corriden R; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Jackson J; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Jacobson S; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Jiao S; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Kassner PD; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Ketcham JM; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Marshall L; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Okano A; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Robles O; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Schwarz J; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Talay O; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Tivitmahaisoon P; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Lester-Zeiner D; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Milestone H; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Trujillo D; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Younai A; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Wustrow DJ; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 12; Vol. 69 (3), pp. 1982-1998. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zibinsky+M%22">Zibinsky M</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Bradford+D%22">Bradford D</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Brockstedt+DG%22">Brockstedt DG</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Corriden+R%22">Corriden R</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Jackson+J%22">Jackson J</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Jacobson+S%22">Jacobson S</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Jiao+S%22">Jiao S</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Kassner+PD%22">Kassner PD</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Ketcham+JM%22">Ketcham JM</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Marshall+L%22">Marshall L</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Okano+A%22">Okano A</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Robles+O%22">Robles O</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Schwarz+J%22">Schwarz J</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Talay+O%22">Talay O</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Tivitmahaisoon+P%22">Tivitmahaisoon P</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Lester-Zeiner+D%22">Lester-Zeiner D</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Milestone+H%22">Milestone H</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Trujillo+D%22">Trujillo D</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Younai+A%22">Younai A</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Wustrow+DJ%22">Wustrow DJ</searchLink>; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Feb 12; Vol. 69 (3), pp. 1982-1998. <i>Date of Electronic Publication: </i>2026 Jan 23.
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        Value: 10.1021/acs.jmedchem.5c01678
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        Text: English
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        StartPage: 1982
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      – TitleFull: Discovery and Characterization of Zelnecirnon (RPT193), a Potent and Selective CCR4 Antagonist for Allergic Disorders.
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