The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer.

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Title: The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer.
Authors: Schultz L; Division of Pediatric Hematology/Oncology/Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford Medicine, Stanford, CA, USA. lioras@stanford.edu., McNerney K; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Lamble AJ; Department of Pediatrics, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Calkoen FG; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Baruchel A; Department of Pediatric Hematology, Hôpital Universitaire Robert Debré, Assistance Publique-Hôpitaux de Paris and Université Paris Cité, Paris, France., Ceppi F; Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department of Woman-Mother-Child, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland., Curran KJ; Department of Pediatrics, Stem Cell Transplantation and Cellular Therapies Service, Memorial Sloan Kettering, New York, NY, USA., Gore L; Children's Hospital Colorado and the University of Colorado School of Medicine, Aurora, CO, USA., Lamb M; Division of Hematology, Oncology, Blood and Bone Marrow Transplant, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA., Maude SL; Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pulsipher MA; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA., Qayed M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA., Ramakrishna S; Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA., Rheingold SR; Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rossig C; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Silbert SK; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Steineck A; MACC Fund Center for Cancer and Blood Disorders, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Summers C; Department of Pediatrics, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Capitini CM; Department of Pediatrics and Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Bhojwani D; Division of Hematology-Oncology, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gardner RA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Ghorashian S; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.; Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, UK., Shah NN; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. nirali.shah@nih.gov.
Source: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2026 Apr; Vol. 23 (4), pp. 260-278. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500077 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4782 (Electronic) Linking ISSN: 17594774 NLM ISO Abbreviation: Nat Rev Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1759-4782
DOI:10.1038/s41571-025-01115-w