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In-situ RhoA editing via heparinylated LNP-microsphere system for rheumatoid arthritis treatment.

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Title: In-situ RhoA editing via heparinylated LNP-microsphere system for rheumatoid arthritis treatment.
Authors: Zhu Y; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China., Wang L; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, P. R. China., Wei Y; Department of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China., Li G; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China., Shi Z; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China., Wang D; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China., Wang Q; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, P. R. China., Wang L; Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, P. R. China. 153027399@qq.com.; Gusu School of Nanjing Medical University, Suzhou, 215000, P. R. China. 153027399@qq.com., Si W; Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, P. R. China. swb20021121@163.com.; Gusu School of Nanjing Medical University, Suzhou, 215000, P. R. China. swb20021121@163.com., Yang X; Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, P. R. China. xingyangsz@njmu.edu.cn.; Gusu School of Nanjing Medical University, Suzhou, 215000, P. R. China. xingyangsz@njmu.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Jan 23; Vol. 24 (1), pp. 166. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In-situ RhoA editing via heparinylated LNP-microsphere system for rheumatoid arthritis treatment.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Orthopaedic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, P. R. China. 153027399@qq.com.; Gusu School of Nanjing Medical University, Suzhou, 215000, P. R. China. 153027399@qq.com.<br /><searchLink fieldCode="AU" term="%22Si+W%22">Si W</searchLink>; Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, P. R. China. swb20021121@163.com.; Gusu School of Nanjing Medical University, Suzhou, 215000, P. R. China. swb20021121@163.com.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, P. R. China. xingyangsz@njmu.edu.cn.; Gusu School of Nanjing Medical University, Suzhou, 215000, P. R. China. xingyangsz@njmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Jan 23; Vol. 24 (1), pp. 166. <i>Date of Electronic Publication: </i>2026 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12951-026-04040-x
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        StartPage: 166
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              Text: 2026 Jan 23
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