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Insights into the human pharmacokinetics and metabolism of branaplam, a splicing modulator of a survival motor neuron-2 and huntingtin pre-mRNAs, in infants and adults.

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Title: Insights into the human pharmacokinetics and metabolism of branaplam, a splicing modulator of a survival motor neuron-2 and huntingtin pre-mRNAs, in infants and adults.
Authors: Lozac'h F; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address: frederic.lozach@novartis.com., Demailly A; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Raccuglia M; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., James AD; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Walles M; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Borowsky B; Global Medical Affairs, Global Drug Development, Novartis Pharma AG, Basel, Switzerland., Faller T; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 Feb; Vol. 54 (2), pp. 100219. Date of Electronic Publication: 2025 Dec 13.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lozac'h+F%22">Lozac'h F</searchLink>; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address: frederic.lozach@novartis.com.<br /><searchLink fieldCode="AU" term="%22Demailly+A%22">Demailly A</searchLink>; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Raccuglia+M%22">Raccuglia M</searchLink>; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22James+AD%22">James AD</searchLink>; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Walles+M%22">Walles M</searchLink>; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Borowsky+B%22">Borowsky B</searchLink>; Global Medical Affairs, Global Drug Development, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Faller+T%22">Faller T</searchLink>; Pharmacokinetic Sciences, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%229421550%22">Drug metabolism and disposition: the biological fate of chemicals</searchLink> [Drug Metab Dispos] 2026 Feb; Vol. 54 (2), pp. 100219. <i>Date of Electronic Publication: </i>2025 Dec 13.
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        Value: 10.1016/j.dmd.2025.100219
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        Text: English
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        StartPage: 100219
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      – TitleFull: Insights into the human pharmacokinetics and metabolism of branaplam, a splicing modulator of a survival motor neuron-2 and huntingtin pre-mRNAs, in infants and adults.
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              Text: 2026 Feb
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              Y: 2026
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