Absolute Bioavailability of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC): Systemic Pharmacokinetics of the CRC-PIPAC-II Trial.

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Title: Absolute Bioavailability of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC): Systemic Pharmacokinetics of the CRC-PIPAC-II Trial.
Authors: van den Heuvel TBM; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.; Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl., Rauwerdink P; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands., Hulshof E; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands., van de Vlasakker VCJ; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands., Pluimakers G; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands., Rovers KPB; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Creemers GJ; Department of Medical Oncology, Catharina Hospital, Eindhoven, The Netherlands., Burger PJWA; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Nienhuijs SW; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Wiezer RJ; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands., Lurvink RJ; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Boerma D; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands., De Hingh IHJT; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.; Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands., Deenen MJ; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
Source: Annals of surgical oncology [Ann Surg Oncol] 2026 Apr; Vol. 33 (4), pp. 3004-3017. Date of Electronic Publication: 2026 Jan 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1534-4681
DOI:10.1245/s10434-025-18874-6