Absolute Bioavailability of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC): Systemic Pharmacokinetics of the CRC-PIPAC-II Trial.

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Title: Absolute Bioavailability of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC): Systemic Pharmacokinetics of the CRC-PIPAC-II Trial.
Authors: van den Heuvel TBM; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.; Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl., Rauwerdink P; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands., Hulshof E; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands., van de Vlasakker VCJ; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands., Pluimakers G; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands., Rovers KPB; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Creemers GJ; Department of Medical Oncology, Catharina Hospital, Eindhoven, The Netherlands., Burger PJWA; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Nienhuijs SW; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Wiezer RJ; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands., Lurvink RJ; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Boerma D; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands., De Hingh IHJT; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.; Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands., Deenen MJ; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
Source: Annals of surgical oncology [Ann Surg Oncol] 2026 Apr; Vol. 33 (4), pp. 3004-3017. Date of Electronic Publication: 2026 Jan 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Absolute Bioavailability of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC): Systemic Pharmacokinetics of the CRC-PIPAC-II Trial.
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  Data: <searchLink fieldCode="AU" term="%22van+den+Heuvel+TBM%22">van den Heuvel TBM</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.; Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. teun.vd.heuvel@catharinaziekenhuis.nl.<br /><searchLink fieldCode="AU" term="%22Rauwerdink+P%22">Rauwerdink P</searchLink>; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hulshof+E%22">Hulshof E</searchLink>; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Vlasakker+VCJ%22">van de Vlasakker VCJ</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Moes+DJAR%22">Moes DJAR</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pluimakers+G%22">Pluimakers G</searchLink>; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rovers+KPB%22">Rovers KPB</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Creemers+GJ%22">Creemers GJ</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+PJWA%22">Burger PJWA</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nienhuijs+SW%22">Nienhuijs SW</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wiezer+RJ%22">Wiezer RJ</searchLink>; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lurvink+RJ%22">Lurvink RJ</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boerma+D%22">Boerma D</searchLink>; Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.<br /><searchLink fieldCode="AU" term="%22De+Hingh+IHJT%22">De Hingh IHJT</searchLink>; Department of Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.; Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Deenen+MJ%22">Deenen MJ</searchLink>; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229420840%22">Annals of surgical oncology</searchLink> [Ann Surg Oncol] 2026 Apr; Vol. 33 (4), pp. 3004-3017. <i>Date of Electronic Publication: </i>2026 Jan 25.
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