Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a model of mucopolysaccharidosis type IVA.

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Title: Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a model of mucopolysaccharidosis type IVA.
Authors: Lee JJ; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Lu PN; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Dukes-Rimsky L; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Jeter C; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Colonna MB; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Poplawski AB; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Arno G; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Hallman J; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA., Underwood C; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA., Basu A; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Pollard L; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA., Weiss RJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Steet R; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Flanagan-Steet H; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Source: Disease models & mechanisms [Dis Model Mech] 2026 Feb 01; Vol. 19 (2). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1754-8411
DOI:10.1242/dmm.052582