Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance.
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| Title: | Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance. |
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| Authors: | Garcia-Robledo JE; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Centro de Investigación en Hematología y Oncología (CIHO), IDC Instituto de Cáncer Hemato Oncólogos, Cali, Colombia., Cabrera-Salcedo S; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia., Brandauer AM; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States., Romano F; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States., Rengifo-Martinez J; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Clinical Research Center, Rio Grande Urology, El Paso, TX, United States., Toro-Pedroza A; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia., Victoria JS; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia., Rios-Serna LJ; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (CIRAT), Universidad Icesi, Cali, Colombia., Loukanov A; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Department of Chemistry and Materials Science, National Institute of Technology, Gunma College, Maebashi, Japan., Cardona AF; Department of Oncology, Centro de Tratamiento e Investigación Sobre Cáncer Luis Carlos Sarmiento Angulo (CTIC), Bogotá, Colombia., Genovese P; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States., Baena JC; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Department of Hematology/Oncology, Fundación Valle del Lili, Cali, Colombia. |
| Source: | Frontiers in oncology [Front Oncol] 2026 Jan 09; Vol. 15, pp. 1698442. Date of Electronic Publication: 2026 Jan 09 (Print Publication: 2025). |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2234-943X |
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| DOI: | 10.3389/fonc.2025.1698442 |
