Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study.

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Title: Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study.
Authors: Vassy JL; VA Boston Healthcare System, Boston, MA, USA. jvassy@bwh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. jvassy@bwh.harvard.edu.; Division of General Internal Medicine, Mass General Brigham, Boston, MA, USA. jvassy@bwh.harvard.edu., Dornisch AM; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA., Karunamuni R; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA., Gatzen M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kachulis CJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Lennon NJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Brunette CA; VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Danowski ME; VA Boston Healthcare System, Boston, MA, USA., Hauger RL; Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.; Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA, USA., Garraway IP; Division of Urology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Kibel AS; Urology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lee KM; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salt Lake City, UT, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salt Lake City, UT, USA., Maxwell KN; Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.; Department of Medicine - Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Ratner D; VA Boston Healthcare System, Boston, MA, USA., Rose BS; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA., Teerlink CC; VA Salt Lake City Healthcare System, Salt Lake City, UT, USA.; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Xu GJ; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA., Hofherr SE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lafferty KA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Larkin K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Malolepsza E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Patterson CJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Toledo DM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Donovan JL; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hamdy FC; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Martin RM; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; NIHR Biomedical Research Centre at the University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK., Neal DE; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; University of Cambridge, Department of Oncology, Cambridge, UK.; Cancer Research UK, Cambridge Research Institute, Cambridge, UK., Turner EL; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Andreassen OA; Centre for Precision Psychiatry and KG Jebsen Centre for Neurodevelopment, Oslo University Hospital and University of Oslo, Oslo, Norway., Dale AM; NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Radiology, University of California San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Halicioglu Data Science Institute, University of California San Diego, La Jolla, CA, USA., Mills IG; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Abraham A; Department of Oncology, Cross Cancer Institute, University of Alberta, Alberta, Canada., Batra J; School of Biomedicine, Faculty of Health and Medical Sciences, Bond University, Gold Coast, Queensland, Australia.; Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Australian Prostate Cancer Bioresource (APCB), QUT, Brisbane, Queensland, Australia.; Translational Research Institute, QUT, Brisbane, Queensland, Australia., Clements J; Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Australian Prostate Cancer Bioresource (APCB), QUT, Brisbane, Queensland, Australia.; Translational Research Institute, QUT, Brisbane, Queensland, Australia., Cussenot O; Sorbonne Université, Paris, France.; Tenon Hospital, Paris, France., Cybulski C; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Eeles RA; The Institute of Cancer Research, London, UK.; Royal Marsden NHS Foundation Trust, London, UK., Fowke JH; Division of Epidemiology, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA., Grindedal EM; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Hamilton RJ; Dept. of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.; Dept. of Surgery (Urology), University of Toronto, Toronto, Ontario, Canada., Lim J; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lu YJ; Centre for Cancer Biomarker and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, UK., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia., Maier C; Zentrum für Humangenetik Tuebingen, Tuebingen, Germany.; Institut für Humangenetik, University of Ulm, Ulm, Germany., Mucci LA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Multigner L; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Parent MÉ; Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, Quebec, Canada.; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Petrovics G; Uniformed Services University, Bethesda, MD, USA.; Center for Prostate Disease Research, Bethesda, MD, USA., Plym A; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Razack A; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Rosenstein BS; Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schleutker J; Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, Turku, Finland., Sørensen KD; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark., Townsend PA; Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK.; The University of Surrey, Guildford, Surrey, UK., Travis RC; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Vega A; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain., West CML; Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK., Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Seibert TM; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. tseibert@health.ucsd.edu.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA. tseibert@health.ucsd.edu.; Department of Radiology, University of California San Diego, La Jolla, CA, USA. tseibert@health.ucsd.edu.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. tseibert@health.ucsd.edu.; Department of Urology, University of California San Diego, La Jolla, CA, USA. tseibert@health.ucsd.edu.
Corporate Authors: Profile Steering Committee, IMPACT Study Steering Committee and Collaborators, PRACTICAL Consortium, VA Million Veteran Program
Source: Nature cancer [Nat Cancer] 2026 Feb; Vol. 7 (2), pp. 352-367. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-1347
DOI:10.1038/s43018-025-01103-0