Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma.

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Title: Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma.
Authors: Fischietti M; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Zannikou M; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Beauchamp EM; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA., Saleiro D; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Baran AH; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA., Hryhorysak BN; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Magaña JNG; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Fajardo EL; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Blyth GT; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Castro BA; Department of Neurological Surgery., Miska JM; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Neurological Surgery., Lee-Chang C; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Neurological Surgery., Patel P; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Bartom ET; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Genetics, and.; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Kocherginsky M; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Eckerdt F; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Platanias LC; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.
Source: JCI insight [JCI Insight] 2026 Jan 27; Vol. 11 (5). Date of Electronic Publication: 2026 Jan 27 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.190031