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Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma.

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Title: Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma.
Authors: Fischietti M; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Zannikou M; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Beauchamp EM; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA., Saleiro D; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Baran AH; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA., Hryhorysak BN; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Magaña JNG; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Fajardo EL; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Blyth GT; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Castro BA; Department of Neurological Surgery., Miska JM; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Neurological Surgery., Lee-Chang C; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Neurological Surgery., Patel P; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA., Bartom ET; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Genetics, and.; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Kocherginsky M; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Eckerdt F; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Platanias LC; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.
Source: JCI insight [JCI Insight] 2026 Jan 27; Vol. 11 (5). Date of Electronic Publication: 2026 Jan 27 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Fischietti+M%22">Fischietti M</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Zannikou+M%22">Zannikou M</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Beauchamp+EM%22">Beauchamp EM</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Saleiro+D%22">Saleiro D</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Baran+AH%22">Baran AH</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Hryhorysak+BN%22">Hryhorysak BN</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Magaña+JNG%22">Magaña JNG</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Fajardo+EL%22">Fajardo EL</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Blyth+GT%22">Blyth GT</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Castro+BA%22">Castro BA</searchLink>; Department of Neurological Surgery.<br /><searchLink fieldCode="AU" term="%22Miska+JM%22">Miska JM</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Neurological Surgery.<br /><searchLink fieldCode="AU" term="%22Lee-Chang+C%22">Lee-Chang C</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Neurological Surgery.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Bartom+ET%22">Bartom ET</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Genetics, and.; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Kocherginsky+M%22">Kocherginsky M</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Eckerdt+F%22">Eckerdt F</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Platanias+LC%22">Platanias LC</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.; Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Jan 27; Vol. 11 (5). <i>Date of Electronic Publication: </i>2026 Jan 27 (<i>Print Publication: </i>2026).
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        Value: 10.1172/jci.insight.190031
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        Text: English
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