Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.

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Title: Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.
Authors: Wang Y; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mohammadi B; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hartmann C; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Klinik und Poliklinik für Neurologie, Universitätsmedizin Rostock, Gehlsheimer Straße 20, 18147, Rostock, Germany., Hartmann K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Thies E; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Matamoros-Angles A; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Faculty of Medicine University of Vic-Central University of Catalonia (UVic-UCC), 08500, Vic, Barcelona, Spain., Fang C; Department of Biochemistry and Cell Biology, Boston University/Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Annovis Bio, 101 Lindenwood Dr., PA 19355, Malvern, USA., Harris DA; Department of Biochemistry and Cell Biology, Boston University/Chobanian & Avedisian School of Medicine, Boston, MA, USA., Tatzelt J; Department of Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; Cluster of Excellence RESOLV, Ruhr University Bochum, Bochum, Germany., Altmeppen HC; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sepulveda-Falla D; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Strittmatter SM; Departments of Neuroscience and Neurology, Yale School of Medicine, New Haven, USA., Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.krasemann@uke.de.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Jan 29; Vol. 14 (1). Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-5960
DOI:10.1186/s40478-026-02235-9