Dupilumab treatment restores epithelial barrier in nonlesional and lesional skin in children with atopic dermatitis.

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Title: Dupilumab treatment restores epithelial barrier in nonlesional and lesional skin in children with atopic dermatitis.
Authors: Cork MJ; Sheffield Children's National Institute for Health and Care Research Commercial Research Delivery Centre, Sheffield, United Kingdom; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom., Ong PY; Division of Allergy and Clinical Immunology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California., Danby SG; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Byers RA; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Matcher SJ; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Katibi OS; Department of Paediatrics & Child Health, University of Ilorin, Ilorin, Nigeria; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom., Brown K; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Andrew PV; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Pinnock A; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Poyner A; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Johnson L; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom., Gormley S; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom., Hyde A; Department of Infection, Immunity and Cardiovascular Disease, Sheffield Dermatology Research, University of Sheffield, Sheffield, United Kingdom., Ramirez-Gama M; Department of Pediatrics, National Jewish Health, Denver, Colorado., Garcia S; Department of Pediatrics, National Jewish Health, Denver, Colorado., Taylor PA; Department of Pediatrics, National Jewish Health, Denver, Colorado., Bologna G; Ividata Life Sciences, contractor for Sanofi, Chilly-Mazarin, France., Praestgaard AH; Sanofi, Cambridge, Massachusetts., Zahn J; Regeneron Pharmaceuticals Inc., Tarrytown, New York., Zhang A; Sanofi, Cambridge, Massachusetts., Leung DYM; Department of Pediatrics, National Jewish Health, Denver, Colorado. Electronic address: LeungD@NJHealth.org.
Source: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2026 May; Vol. 136 (5), pp. 558-564.e3. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: American College of Allergy, Asthma, and Immunology Country of Publication: United States NLM ID: 9503580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4436 (Electronic) Linking ISSN: 10811206 NLM ISO Abbreviation: Ann Allergy Asthma Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1534-4436
DOI:10.1016/j.anai.2026.01.008