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Dupilumab treatment restores epithelial barrier in nonlesional and lesional skin in children with atopic dermatitis.

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Title: Dupilumab treatment restores epithelial barrier in nonlesional and lesional skin in children with atopic dermatitis.
Authors: Cork MJ; Sheffield Children's National Institute for Health and Care Research Commercial Research Delivery Centre, Sheffield, United Kingdom; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom., Ong PY; Division of Allergy and Clinical Immunology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California., Danby SG; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Byers RA; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Matcher SJ; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Katibi OS; Department of Paediatrics & Child Health, University of Ilorin, Ilorin, Nigeria; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom., Brown K; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Andrew PV; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Pinnock A; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Poyner A; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom., Johnson L; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom., Gormley S; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom., Hyde A; Department of Infection, Immunity and Cardiovascular Disease, Sheffield Dermatology Research, University of Sheffield, Sheffield, United Kingdom., Ramirez-Gama M; Department of Pediatrics, National Jewish Health, Denver, Colorado., Garcia S; Department of Pediatrics, National Jewish Health, Denver, Colorado., Taylor PA; Department of Pediatrics, National Jewish Health, Denver, Colorado., Bologna G; Ividata Life Sciences, contractor for Sanofi, Chilly-Mazarin, France., Praestgaard AH; Sanofi, Cambridge, Massachusetts., Zahn J; Regeneron Pharmaceuticals Inc., Tarrytown, New York., Zhang A; Sanofi, Cambridge, Massachusetts., Leung DYM; Department of Pediatrics, National Jewish Health, Denver, Colorado. Electronic address: LeungD@NJHealth.org.
Source: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2026 May; Vol. 136 (5), pp. 558-564.e3. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: American College of Allergy, Asthma, and Immunology Country of Publication: United States NLM ID: 9503580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4436 (Electronic) Linking ISSN: 10811206 NLM ISO Abbreviation: Ann Allergy Asthma Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dupilumab treatment restores epithelial barrier in nonlesional and lesional skin in children with atopic dermatitis.
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  Data: <searchLink fieldCode="AU" term="%22Cork+MJ%22">Cork MJ</searchLink>; Sheffield Children's National Institute for Health and Care Research Commercial Research Delivery Centre, Sheffield, United Kingdom; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ong+PY%22">Ong PY</searchLink>; Division of Allergy and Clinical Immunology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Danby+SG%22">Danby SG</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Byers+RA%22">Byers RA</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Matcher+SJ%22">Matcher SJ</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Katibi+OS%22">Katibi OS</searchLink>; Department of Paediatrics & Child Health, University of Ilorin, Ilorin, Nigeria; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brown+K%22">Brown K</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Andrew+PV%22">Andrew PV</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pinnock+A%22">Pinnock A</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Poyner+A%22">Poyner A</searchLink>; Sheffield Dermatology Research, Division of Clinical Medicine, University of Sheffield Medical School, Sheffield, United Kingdom; National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Johnson+L%22">Johnson L</searchLink>; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gormley+S%22">Gormley S</searchLink>; Sheffield Children's National Health Service Foundation Trust, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hyde+A%22">Hyde A</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, Sheffield Dermatology Research, University of Sheffield, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ramirez-Gama+M%22">Ramirez-Gama M</searchLink>; Department of Pediatrics, National Jewish Health, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Garcia+S%22">Garcia S</searchLink>; Department of Pediatrics, National Jewish Health, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Taylor+PA%22">Taylor PA</searchLink>; Department of Pediatrics, National Jewish Health, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Bologna+G%22">Bologna G</searchLink>; Ividata Life Sciences, contractor for Sanofi, Chilly-Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Praestgaard+AH%22">Praestgaard AH</searchLink>; Sanofi, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Zahn+J%22">Zahn J</searchLink>; Regeneron Pharmaceuticals Inc., Tarrytown, New York.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; Sanofi, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Leung+DYM%22">Leung DYM</searchLink>; Department of Pediatrics, National Jewish Health, Denver, Colorado. Electronic address: LeungD@NJHealth.org.
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