Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1.

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Title: Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1.
Authors: Li J; Shanghai Institute of Infectious Disease and Biosecurity, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China., Jiang W; School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China., Tu G; Cardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China., Zhong Z; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China., Luo Z; Cardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China. luo.zhe@zs-hospital.sh.cn., Horng T; School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China. tsyhorng@shanghaitech.edu.cn., Miao C; Shanghai Institute of Infectious Disease and Biosecurity, Zhongshan Hospital, Fudan University, Shanghai, China. miaochh@aliyun.com.; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China. miaochh@aliyun.com.
Source: British journal of cancer [Br J Cancer] 2026 Apr; Vol. 134 (7), pp. 1042-1056. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-1827
DOI:10.1038/s41416-025-03319-4