Effect of Canagliflozin Pretreatment on the Efficacy of Insulin Therapy to Rescue Type 1 Diabetes-Related Bone Fragility in Male Mice.

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Title: Effect of Canagliflozin Pretreatment on the Efficacy of Insulin Therapy to Rescue Type 1 Diabetes-Related Bone Fragility in Male Mice.
Authors: Nyman JS; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st, Ave. S., Suite 4200, Nashville, TN, 37232, USA. jeffry.s.nyman@vumc.org.; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232, USA. jeffry.s.nyman@vumc.org.; United States Department of Veterans Affairs, Tennessee Valley Healthcare System, 1310 24th Ave. S., Nashville, TN, 37212, USA. jeffry.s.nyman@vumc.org., Bunn RC; Department of Pediatrics and Barnstable Brown Diabetes Center, University of Kentucky, 830 S. Limestone St., Lexington, KY, 40536, USA., Uppuganti S; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st, Ave. S., Suite 4200, Nashville, TN, 37232, USA., Hennen EM; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232, USA., Mishra P; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st, Ave. S., Suite 4200, Nashville, TN, 37232, USA., Ray PD; Department of Pediatrics and Barnstable Brown Diabetes Center, University of Kentucky, 830 S. Limestone St., Lexington, KY, 40536, USA., Mendez AG; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232, USA., Kalaitzoglou E; Department of Pediatrics and Barnstable Brown Diabetes Center, University of Kentucky, 830 S. Limestone St., Lexington, KY, 40536, USA., Fowlkes JL; Department of Pediatrics and Barnstable Brown Diabetes Center, University of Kentucky, 830 S. Limestone St., Lexington, KY, 40536, USA. fowlkesjohnl@uky.edu.
Source: Calcified tissue international [Calcif Tissue Int] 2026 Jan 31; Vol. 117 (1), pp. 20. Date of Electronic Publication: 2026 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0827
DOI:10.1007/s00223-026-01486-x