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Mapping cellular vulnerability in Parkinson's disease using retro-AAVs and preformed α-synuclein fibrils.

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Title: Mapping cellular vulnerability in Parkinson's disease using retro-AAVs and preformed α-synuclein fibrils.
Authors: Geibl FF; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany.; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Musa AAS; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany., Dietrich L; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany., Wolter H; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany., Wokosin DL; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Khudayberdiev S; Molecular Neurobiology Group, Institute of Physiological Chemistry, Marburg University, 35032, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus-Liebig-University Giessen, 35032, Marburg, Germany., Rust MB; Molecular Neurobiology Group, Institute of Physiological Chemistry, Marburg University, 35032, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus-Liebig-University Giessen, 35032, Marburg, Germany., Chen R; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, 20815, USA., Oertel WH; Department of Neurology, Marburg University, 35043, Marburg, Germany., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, 20815, USA., Henrich MT; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany. martin.henrich@uni-marburg.de.; Department of Neurology, Marburg University, 35043, Marburg, Germany. martin.henrich@uni-marburg.de.; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. martin.henrich@uni-marburg.de.
Source: Translational neurodegeneration [Transl Neurodegener] 2026 Jan 30; Vol. 15 (1), pp. 2. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101591861 Publication Model: Electronic Cited Medium: Print ISSN: 2047-9158 (Print) Linking ISSN: 20479158 NLM ISO Abbreviation: Transl Neurodegener Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Geibl+FF%22">Geibl FF</searchLink>; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany.; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Musa+AAS%22">Musa AAS</searchLink>; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dietrich+L%22">Dietrich L</searchLink>; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wolter+H%22">Wolter H</searchLink>; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany.; Department of Neurology, Marburg University, 35043, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wokosin+DL%22">Wokosin DL</searchLink>; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Khudayberdiev+S%22">Khudayberdiev S</searchLink>; Molecular Neurobiology Group, Institute of Physiological Chemistry, Marburg University, 35032, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus-Liebig-University Giessen, 35032, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rust+MB%22">Rust MB</searchLink>; Molecular Neurobiology Group, Institute of Physiological Chemistry, Marburg University, 35032, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus-Liebig-University Giessen, 35032, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Dawson+VL%22">Dawson VL</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Dawson+TM%22">Dawson TM</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Oertel+WH%22">Oertel WH</searchLink>; Department of Neurology, Marburg University, 35043, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Surmeier+DJ%22">Surmeier DJ</searchLink>; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Henrich+MT%22">Henrich MT</searchLink>; Department of Psychiatry and Psychotherapy, Marburg University, Rudolf-Bultmann-Str. 8, 35043, Marburg, Germany. martin.henrich@uni-marburg.de.; Department of Neurology, Marburg University, 35043, Marburg, Germany. martin.henrich@uni-marburg.de.; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. martin.henrich@uni-marburg.de.
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