Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.

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Bibliographic Details
Title: Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.
Authors: Jeskanen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Kervinen I; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Lehtisalo J; Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Ngandu T; Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Willman RM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Rosa J; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Hoffmann D; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Leinonen V; Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland, Kuopio, Finland., Haapasalo A; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Takalo M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. mari.takalo@uef.fi., Martiskainen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. henna.martiskainen@uef.fi., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. mikko.hiltunen@uef.fi.
Corporate Authors: FinnGen
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Jan 31; Vol. 18 (1). Date of Electronic Publication: 2026 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1758-9193
DOI:10.1186/s13195-026-01957-1