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Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.

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Title: Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.
Authors: Jeskanen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Kervinen I; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Lehtisalo J; Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Ngandu T; Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Willman RM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Rosa J; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Hoffmann D; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Leinonen V; Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland, Kuopio, Finland., Haapasalo A; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Takalo M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. mari.takalo@uef.fi., Martiskainen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. henna.martiskainen@uef.fi., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. mikko.hiltunen@uef.fi.
Corporate Authors: FinnGen
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Jan 31; Vol. 18 (1). Date of Electronic Publication: 2026 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.
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  Data: <searchLink fieldCode="AU" term="%22Jeskanen+H%22">Jeskanen H</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Heikkinen+S%22">Heikkinen S</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Kervinen+I%22">Kervinen I</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Lehtisalo+J%22">Lehtisalo J</searchLink>; Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Ngandu+T%22">Ngandu T</searchLink>; Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Willman+RM%22">Willman RM</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Rosa+J%22">Rosa J</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hoffmann+D%22">Hoffmann D</searchLink>; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Leinonen+V%22">Leinonen V</searchLink>; Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Haapasalo+A%22">Haapasalo A</searchLink>; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Takalo+M%22">Takalo M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. mari.takalo@uef.fi.<br /><searchLink fieldCode="AU" term="%22Martiskainen+H%22">Martiskainen H</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. henna.martiskainen@uef.fi.<br /><searchLink fieldCode="AU" term="%22Hiltunen+M%22">Hiltunen M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. mikko.hiltunen@uef.fi.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2026 Jan 31; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Jan 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Jan 31
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