Exploring MAO inhibitory activity of 5-hydroxy regioisomers of hispidol's analogs leads to identification of novel highly selective MAO-B open-conformation inhibitors.

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Title: Exploring MAO inhibitory activity of 5-hydroxy regioisomers of hispidol's analogs leads to identification of novel highly selective MAO-B open-conformation inhibitors.
Authors: Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.; Institute of Regulatory Innovation Through Science, Kyung Hee University, Seoul, 02447, Republic of Korea., Kim R; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea., Yoo SY; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea., El-Halaby LO; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El-Sayed SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt., Kim M; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea., Kim HJ; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea., Park KD; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea., Sim J; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.; Institute of Regulatory Innovation Through Science, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr., Lee YS; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. kyslee@khu.ac.kr.; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. kyslee@khu.ac.kr.
Source: Molecular diversity [Mol Divers] 2026 Aug; Vol. 30 (4), pp. 5871-5888. Date of Electronic Publication: 2026 Feb 01.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1573-501X
DOI:10.1007/s11030-025-11464-4