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Exploring MAO inhibitory activity of 5-hydroxy regioisomers of hispidol's analogs leads to identification of novel highly selective MAO-B open-conformation inhibitors.

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Title: Exploring MAO inhibitory activity of 5-hydroxy regioisomers of hispidol's analogs leads to identification of novel highly selective MAO-B open-conformation inhibitors.
Authors: Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.; Institute of Regulatory Innovation Through Science, Kyung Hee University, Seoul, 02447, Republic of Korea., Kim R; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea., Yoo SY; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea., El-Halaby LO; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El-Sayed SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt., Kim M; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea., Kim HJ; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea., Park KD; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea., Sim J; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.; Institute of Regulatory Innovation Through Science, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr., Lee YS; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. kyslee@khu.ac.kr.; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. kyslee@khu.ac.kr.
Source: Molecular diversity [Mol Divers] 2026 Aug; Vol. 30 (4), pp. 5871-5888. Date of Electronic Publication: 2026 Feb 01.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE; In Process
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  Data: Exploring MAO inhibitory activity of 5-hydroxy regioisomers of hispidol's analogs leads to identification of novel highly selective MAO-B open-conformation inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Hassan+AHE%22">Hassan AHE</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.; Institute of Regulatory Innovation Through Science, Kyung Hee University, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+R%22">Kim R</searchLink>; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoo+SY%22">Yoo SY</searchLink>; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22El-Halaby+LO%22">El-Halaby LO</searchLink>; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+SM%22">El-Sayed SM</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+KD%22">Park KD</searchLink>; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sim+J%22">Sim J</searchLink>; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.; Institute of Regulatory Innovation Through Science, Kyung Hee University, Seoul, 02447, Republic of Korea. jsim@khu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. kyslee@khu.ac.kr.; Department of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. kyslee@khu.ac.kr.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ESCOM+Science+Publishers%22">ESCOM Science Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9516534 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-501X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213811991%22">13811991 </searchLink><i>NLM ISO Abbreviation: </i>Mol Divers <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1007/s11030-025-11464-4
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              Text: 2026 Aug
              Type: published
              Y: 2026
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