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Cost-utility-analysis of molecular-integrated-profile for women with (high)intermediate risk endometrial cancer - PORTEC-4a an international, randomised, phase 3 trial.

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Title: Cost-utility-analysis of molecular-integrated-profile for women with (high)intermediate risk endometrial cancer - PORTEC-4a an international, randomised, phase 3 trial.
Authors: van den Heerik ASVM; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: a.v.m.van_den_heerik@lumc.nl., Horeweg N; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., Haverkort MAD; Department of Radiation Oncology, Radiotherapiegroep, Arnhem, The Netherlands., Kuijsters N; Maastro, Maastricht, The Netherlands., Kommoss S; Department of Women's Health, Tübingen University Hospital, Tübingen and Diak Klinikum, Department of Gynecology & Obstetrics, Schwaebisch Hall, Germany., Koppe FLA; Institute Verbeeten, Tilburg, The Netherlands., Nowee ME; Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Westerveld H; Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands; Department of Radiotherapy, Erasmus MC - Cancer Institute, University of Rotterdam, Rotterdam, The Netherlands., de Jong MAA; Radiotherapeutisch Instituut Friesland, Leeuwarden, The Netherlands., Frühauf F; Department of Gynaecology, Obstetrics and Neonatology, General University Hospital Prague, First Medical Faculty of the Charles University, Czech Republic., Cnossen JS; Department of Radiotherapy, Catharina Hospital Eindhoven, The Netherlands., Mens JWM; Department of Radiotherapy, Erasmus MC - Cancer Institute, University of Rotterdam, Rotterdam, The Netherlands., Beukema JC; Department of Radiotherapy, University Medical Center Groningen, Groningen, The Netherlands., Chargari C; Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France., Gillham C; Department of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland and Caner Trials Ireland, Ireland., Tseng DSJ; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Vandecasteele K; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Hamann M; Department of Gynecology, Rotkreuzklinikum München, Germany., Kiderlen M; Department of Radiation Oncology, Haaglanden Medisch Centrum, Leidschendam, The Netherlands., Polterauer S; Department of Obstetrics and Gynaecology, University Hospital Vienna, Vienna, Austria., Staebler A; Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany., Nijman HW; Department of Gynecology, University Medical Center Groningen, Groningen, The Netherlands., Wortman BG; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiotherapy, Catharina Hospital Eindhoven, The Netherlands., De Boer SM; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., Verhoeven-Adema KW; Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands., Nout RA; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiotherapy, Erasmus MC - Cancer Institute, University of Rotterdam, Rotterdam, The Netherlands., Putter H; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., Smit VTHBM; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Creutzberg CL; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., van den Hout WB; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Source: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2026 Apr; Vol. 217, pp. 111406. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cost-utility-analysis of molecular-integrated-profile for women with (high)intermediate risk endometrial cancer - PORTEC-4a an international, randomised, phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22van+den+Heerik+ASVM%22">van den Heerik ASVM</searchLink>; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: a.v.m.van_den_heerik@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Horeweg+N%22">Horeweg N</searchLink>; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Haverkort+MAD%22">Haverkort MAD</searchLink>; Department of Radiation Oncology, Radiotherapiegroep, Arnhem, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuijsters+N%22">Kuijsters N</searchLink>; Maastro, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kommoss+S%22">Kommoss S</searchLink>; Department of Women's Health, Tübingen University Hospital, Tübingen and Diak Klinikum, Department of Gynecology & Obstetrics, Schwaebisch Hall, Germany.<br /><searchLink fieldCode="AU" term="%22Koppe+FLA%22">Koppe FLA</searchLink>; Institute Verbeeten, Tilburg, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nowee+ME%22">Nowee ME</searchLink>; Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Westerveld+H%22">Westerveld H</searchLink>; Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands; Department of Radiotherapy, Erasmus MC - Cancer Institute, University of Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jong+MAA%22">de Jong MAA</searchLink>; Radiotherapeutisch Instituut Friesland, Leeuwarden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Frühauf+F%22">Frühauf F</searchLink>; Department of Gynaecology, Obstetrics and Neonatology, General University Hospital Prague, First Medical Faculty of the Charles University, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Cnossen+JS%22">Cnossen JS</searchLink>; Department of Radiotherapy, Catharina Hospital Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mens+JWM%22">Mens JWM</searchLink>; Department of Radiotherapy, Erasmus MC - Cancer Institute, University of Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Beukema+JC%22">Beukema JC</searchLink>; Department of Radiotherapy, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chargari+C%22">Chargari C</searchLink>; Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Gillham+C%22">Gillham C</searchLink>; Department of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland and Caner Trials Ireland, Ireland.<br /><searchLink fieldCode="AU" term="%22Tseng+DSJ%22">Tseng DSJ</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vandecasteele+K%22">Vandecasteele K</searchLink>; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Hamann+M%22">Hamann M</searchLink>; Department of Gynecology, Rotkreuzklinikum München, Germany.<br /><searchLink fieldCode="AU" term="%22Kiderlen+M%22">Kiderlen M</searchLink>; Department of Radiation Oncology, Haaglanden Medisch Centrum, Leidschendam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Polterauer+S%22">Polterauer S</searchLink>; Department of Obstetrics and Gynaecology, University Hospital Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Staebler+A%22">Staebler A</searchLink>; Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Nijman+HW%22">Nijman HW</searchLink>; Department of Gynecology, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wortman+BG%22">Wortman BG</searchLink>; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiotherapy, Catharina Hospital Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22De+Boer+SM%22">De Boer SM</searchLink>; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verhoeven-Adema+KW%22">Verhoeven-Adema KW</searchLink>; Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nout+RA%22">Nout RA</searchLink>; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiotherapy, Erasmus MC - Cancer Institute, University of Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Putter+H%22">Putter H</searchLink>; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Smit+VTHBM%22">Smit VTHBM</searchLink>; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Creutzberg+CL%22">Creutzberg CL</searchLink>; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Hout+WB%22">van den Hout WB</searchLink>; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%228407192%22">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</searchLink> [Radiother Oncol] 2026 Apr; Vol. 217, pp. 111406. <i>Date of Electronic Publication: </i>2026 Jan 30.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers%22">Elsevier Scientific Publishers </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>8407192 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0887 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201678140%22">01678140 </searchLink><i>NLM ISO Abbreviation: </i>Radiother Oncol <i>Subsets: </i>MEDLINE
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