Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence.
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| Title: | Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence. |
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| Authors: | Ali MRA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. ragab_2000006@pharm.bsu.edu.eg., Messiha BAS; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Abdel-Samea AS; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, New Minia City, 61111, Egypt., Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Mohyeldin RH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, New Minia City, 61111, Egypt. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Apr; Vol. 399 (7), pp. 10281-10301. Date of Electronic Publication: 2026 Feb 02. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1432-1912 |
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| DOI: | 10.1007/s00210-026-04994-7 |
