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Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence.

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Title: Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence.
Authors: Ali MRA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. ragab_2000006@pharm.bsu.edu.eg., Messiha BAS; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Abdel-Samea AS; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, New Minia City, 61111, Egypt., Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Mohyeldin RH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, New Minia City, 61111, Egypt.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Apr; Vol. 399 (7), pp. 10281-10301. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence.
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  Data: <searchLink fieldCode="AU" term="%22Ali+MRA%22">Ali MRA</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. ragab_2000006@pharm.bsu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Messiha+BAS%22">Messiha BAS</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdel-Samea+AS%22">Abdel-Samea AS</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, New Minia City, 61111, Egypt.<br /><searchLink fieldCode="AU" term="%22Attya+ME%22">Attya ME</searchLink>; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohyeldin+RH%22">Mohyeldin RH</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, New Minia City, 61111, Egypt.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 Apr; Vol. 399 (7), pp. 10281-10301. <i>Date of Electronic Publication: </i>2026 Feb 02.
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        Value: 10.1007/s00210-026-04994-7
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      – TitleFull: Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence.
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              Text: 2026 Apr
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