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Targeting ENO1 reprograms macrophage polarization to trigger antitumor immunity and improves the therapeutic effect of radiotherapy.

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Title: Targeting ENO1 reprograms macrophage polarization to trigger antitumor immunity and improves the therapeutic effect of radiotherapy.
Authors: Lin YS; Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan., Chang HY; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan., Hong WZ; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen JY; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan., Huang WC; HuniLife Biotechnology, Taipei City, Taiwan., Yuan TT; HuniLife Biotechnology, Taipei City, Taiwan., Ke TW; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Tsai YY; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Chen TH; Department of Surgery, China Medical University Hospital, Taichung, Taiwan., Liang JA; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chao JI; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-Devices, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Chao KSC; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. flylerd0425@gmail.com.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan. flylerd0425@gmail.com.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. flylerd0425@gmail.com.; Office of Research and Development, Asia University, Taichung, Taiwan. flylerd0425@gmail.com.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 02; Vol. 17 (1), pp. 194. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting ENO1 reprograms macrophage polarization to trigger antitumor immunity and improves the therapeutic effect of radiotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Lin+YS%22">Lin YS</searchLink>; Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+HY%22">Chang HY</searchLink>; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+WZ%22">Hong WZ</searchLink>; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+WC%22">Huang WC</searchLink>; HuniLife Biotechnology, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuan+TT%22">Yuan TT</searchLink>; HuniLife Biotechnology, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ke+TW%22">Ke TW</searchLink>; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+YY%22">Tsai YY</searchLink>; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TH%22">Chen TH</searchLink>; Department of Surgery, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+JA%22">Liang JA</searchLink>; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+JI%22">Chao JI</searchLink>; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-Devices, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+KSC%22">Chao KSC</searchLink>; Center of Proton Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KC%22">Huang KC</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. flylerd0425@gmail.com.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan. flylerd0425@gmail.com.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. flylerd0425@gmail.com.; Office of Research and Development, Asia University, Taichung, Taiwan. flylerd0425@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Feb 02; Vol. 17 (1), pp. 194. <i>Date of Electronic Publication: </i>2026 Feb 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41419-026-08416-7
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              Text: 2026 Feb 02
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              Y: 2026
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