A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion.

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Title: A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion.
Authors: Watson CJE; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK., Macdonald S; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., White D; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Bridgeman C; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Gaurav R; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Swift L; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Webster R; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Iype S; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Crick K; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Pollok JM; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Ceresa CDL; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Paul S; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Martin J; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Currie I; Scottish Liver Transplant Unit, Royal Infirmary, Edinburgh, UK., Foukaneli T; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.; Department of Haematology, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Kosmoliaptsis V; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK., Butler AJ; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.
Source: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2026 Jul 01; Vol. 32 (7), pp. 978-990. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 100909185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-6473 (Electronic) Linking ISSN: 15276465 NLM ISO Abbreviation: Liver Transpl Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1527-6473
DOI:10.1097/LVT.0000000000000814