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A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion.

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Title: A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion.
Authors: Watson CJE; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK., Macdonald S; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., White D; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Bridgeman C; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Gaurav R; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Swift L; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Webster R; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Iype S; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Crick K; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Pollok JM; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Ceresa CDL; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK., Paul S; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Martin J; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Currie I; Scottish Liver Transplant Unit, Royal Infirmary, Edinburgh, UK., Foukaneli T; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.; Department of Haematology, Cambridge University Hospitals National Health Service Trust, Cambridge, UK., Kosmoliaptsis V; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK., Butler AJ; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.
Source: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2026 Jul 01; Vol. 32 (7), pp. 978-990. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 100909185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-6473 (Electronic) Linking ISSN: 15276465 NLM ISO Abbreviation: Liver Transpl Subsets: MEDLINE
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  Data: A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion.
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  Data: <searchLink fieldCode="AU" term="%22Watson+CJE%22">Watson CJE</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Macdonald+S%22">Macdonald S</searchLink>; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22White+D%22">White D</searchLink>; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bridgeman+C%22">Bridgeman C</searchLink>; Specialist Haemostasis Laboratory, Cambridge University Hospitals National Health Service Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gaurav+R%22">Gaurav R</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Swift+L%22">Swift L</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Webster+R%22">Webster R</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Iype+S%22">Iype S</searchLink>; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Crick+K%22">Crick K</searchLink>; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pollok+JM%22">Pollok JM</searchLink>; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ceresa+CDL%22">Ceresa CDL</searchLink>; Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Royal Free London NHS Foundation Trust, London; and the Division of Surgery and Interventional Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Paul+S%22">Paul S</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Martin+J%22">Martin J</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Upponi+SS%22">Upponi SS</searchLink>; Department of Radiology, Cambridge University Hospitals National Health Service Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Currie+I%22">Currie I</searchLink>; Scottish Liver Transplant Unit, Royal Infirmary, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Foukaneli+T%22">Foukaneli T</searchLink>; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.; Department of Haematology, Cambridge University Hospitals National Health Service Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kosmoliaptsis+V%22">Kosmoliaptsis V</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Butler+AJ%22">Butler AJ</searchLink>; The Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; The National Institute for Health and Care Research (NIHR) Blood and Transplant Research Unit in Organ Donation and Transplantation (NIHR203332), UK.; The NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge, UK.
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  Data: <searchLink fieldCode="JN" term="%22100909185%22">Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society</searchLink> [Liver Transpl] 2026 Jul 01; Vol. 32 (7), pp. 978-990. <i>Date of Electronic Publication: </i>2026 Feb 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Inc%22">Wolters Kluwer Health, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100909185 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-6473 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215276465%22">15276465 </searchLink><i>NLM ISO Abbreviation: </i>Liver Transpl <i>Subsets: </i>MEDLINE
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