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Development of a chaperone-mediated protein degrader targeting ERK5 that efficaciously reduces tumor growth.

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Title: Development of a chaperone-mediated protein degrader targeting ERK5 that efficaciously reduces tumor growth.
Authors: Yang X; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Yin W; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Xu M; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Tusa I; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, 50134, Italy., Menconi A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, 50134, Italy., Dai Y; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Ding Q; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Wang G; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Foley KP; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China., Rovida E; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, 50134, Italy. elisabetta.rovida@unifi.it., Ying W; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China. wying@ranoktherapeutics.com.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Feb 03; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41634806
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Development of a chaperone-mediated protein degrader targeting ERK5 that efficaciously reduces tumor growth.
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  Data: <searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Yin+W%22">Yin W</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Tusa+I%22">Tusa I</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, 50134, Italy.<br /><searchLink fieldCode="AU" term="%22Menconi+A%22">Menconi A</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, 50134, Italy.<br /><searchLink fieldCode="AU" term="%22Dai+Y%22">Dai Y</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Ding+Q%22">Ding Q</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Foley+KP%22">Foley KP</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Rovida+E%22">Rovida E</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, 50134, Italy. elisabetta.rovida@unifi.it.<br /><searchLink fieldCode="AU" term="%22Ying+W%22">Ying W</searchLink>; Ranok Therapeutics (Hangzhou), Inc, Hangzhou, Zhejiang, 310018, China. wying@ranoktherapeutics.com.
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  Data: <searchLink fieldCode="JN" term="%22101170464%22">Cell communication and signaling : CCS</searchLink> [Cell Commun Signal] 2026 Feb 03; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Feb 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170464 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-811X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221478811X%22">1478811X </searchLink><i>NLM ISO Abbreviation: </i>Cell Commun Signal <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12964-026-02682-w
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        Text: English
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              Text: 2026 Feb 03
              Type: published
              Y: 2026
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